Maybe. If you are lucky, you have very good circulation, well-routed nerves, strong wrists and hands, and you can tough it out. But long days in the saddle can wear you down, and in the long run, it's best to take care of yourself. Depending on you and the bike, vibrations can get seriously harmful to your health. Vibrating bars can worsen carpal tunnel syndrome and arthritis, aggravate circulatory problems, cause numb or tingling hands, etc. If this happens to you, take it seriously. Most of these problems get aggravated more, the more they get aggravated. Give your wrists a break! See our article about Hand Trouble for more information.